Os robôs da natureza apontam para o design
1. Máquinas, robôs, linhas de produção de manufatura totalmente automatizadas, transportadores, turbinas, transistores, computadores e fábricas são sempre configurados por designers inteligentes
2. A ciência descobriu que as células são literalmente nanofábricas químicas que operam com base em máquinas moleculares, robôs de proteína, transportadores de proteína cinesina, linhas de produção autônomas autorreguladas, geram energia por meio de turbinas, transistores de neurônios e computadores
3. Portanto, muito provavelmente, as fábricas de células contendo todas essas coisas são o produto de um projetista inteligente.
https://reasonandscience.catsboard.com/t2978-nature-s-robots-point-to-design
Máquinas moleculares
https://reasonandscience.catsboard.com/t1289-molecular-machines-in-biology
https://en.wikipedia.org/wiki/Molecular_machine
Science papers:
1.“Biological machines: from mills to molecules,” Nature Reviews Molecular Cell Biology, Vol. 1:149-153 (November, 2000).
2.Thomas Köcher & Giulio Superti-Furga, "Mass spectrometry-based functional proteomics: from molecular machines to protein networks," Nature Methods (October, 2007).
3."Crystalline Molecular Machines: A Quest Toward Solid-State Dynamics and Function," Accounts of Chemical Research, Vol. 39(6):413-422 (2006).
4."Molecular Machines," Annual Review of Biomedical Engineering, Vol. 6:363-395 (2004).
5."The Closest Look Ever At The Cell's Machines,” ScienceDaily.com (January 24, 2006).
6."The Cell as a Collection of Protein Machines: Preparing the Next Generation of Molecular Biologists," Cell, Vol. 92:291 (February 6, 1998).
7.Walter Neupert, "Highlight: Molecular Machines," Biological Chemistry, Vol. 386:711(August, 2005).
8.Seiji Kojima and David F. Blair, “The Bacterial Flagellar Motor: Structure and Function of a Complex Molecular Machine,” International Review of Cytology, Vol. 233:93-134 (2004).
9.Hugo ten Cate, “The blood coagulation system as a molecular machine,” BioEssays, Vol. 25:1220-1228 (2003).
10.John L Woolford, Jr, “Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines,” Current Opinion in Cell Biology, Vol. 21(1):109-118 (February, 2009).
11.Reinhard Lührmann, "The Spliceosome: Design Principles of a Dynamic RNP Machine," Cell, Vol. 136: 701-718 (February 20, 2009).
12.Timothy W. Nilsen, "The spliceosome: the most complex macromolecular machine in the cell?," BioEssays, Vol. 25:1147-1149 (2003).
13.L. Yarmush, "Molecular Machines," Annual Review of Biomedical Engineering, Vol. 6:363-395 (2004);
14.Paul D. Boyer, "The ATP Synthase--A Splendid Molecular Machine," Vol. 66:717-749 (1997);
15.Steven M. Block, "Real engines of creation," Nature, Vol. 386:217-219 (March 20, 1997).
16.C. Mavroidis, A. Dubey, and M.L. Yarmush, "Molecular Machines," Annual Review of Biomedical Engineering, Vol. 6:363-395 (2004)
17.Ronald D. Vale, “The Molecular Motor Toolbox for Intracellular Transport,” Cell, Vol. 112:467-480 (February 21, 2003).
18.Sharyn A. Endow, “Kinesin motors as molecular machines,” BioEssays, Vol. 25:1212-1219 (2003).
19.Michiel Meijer, “Mitochondrial biogenesis: The Tom and Tim machine,” Current Biology, Vol. 7:R100-R103 (1997).
20.Maurizio Brunori, "Structure and function of a molecular machine: cytochrome c oxidase," Biophysical Chemistry, Vol. 54: 1-33 (1995).
21.Robert T. Sauer, “Structures of Asymmetric ClpX Hexamers Reveal Nucleotide-Dependent Motions in a AAA+ Protein-Unfolding Machine,” Cell, Vol. 139:744-756 (November 13, 2009).
Proteins are robots
Nature's robots: A history of proteins: Tanford, C., Reynolds, J
Shape-shifting molecular robots respond to DNA signals
When Nature's Robots Go Rogue: Exploring Protein ...
- Document - Nature's Robots: a History of Proteins - Gale
Bio-Inspired Self-Organizing Robotic Systems
GACR - Proteins - Multi-robot Systems
Buy Nature's Robots: A History of Proteins Book Online at Low ...
Molecular production lines
A molecular production line | Nature Chemistry
molecular assembly line | News and features
The molecular biology of production cell lines. - NCBI
Cell-Like 'Molecular Assembly Lines' of ... - Cordis
Biologically inspired molecular assembly lines - MIT Media Lab
DNA-based assembly lines and nanofactories
Cell factories
https://reasonandscience.catsboard.com/t2245-abiogenesis-the-factory-maker-argument
Microbial cell factory is an approach to bioengineering which considers microbial cells as a production facility in which the optimization process largely depends on metabolic engineering
https://en.wikipedia.org/wiki/Microbial_cell_factory
Science papers:
The Molecular Fabric of Cells BIOTOL, B.C. Currell and R C.E Dam-Mieras (Auth.)
Plant Cells as Chemical Factories: Control and Recovery of Valuable Products
Fine Tuning our Cellular Factories: Sirtuins in Mitochondrial Biology
Cells As Molecular Factories
Eukaryotic cells are molecular factories in two senses: cells produce molecules and cells are made up of molecules.
Ribosome: Lessons of a molecular factory construction
Nucleolus: the ribosome factory
Ribosome: The cell city's factories
The Cell's Protein Factory in Action
What looks like a jumble of rubber bands and twisty ties is the ribosome, the cellular protein factory.
Chloroplasts are the microscopic factories on which all life on Earth is based.
Visualization of the active expression site locus by tagging with green fluorescent protein shows that it is specifically located at this unique pol I transcriptional factory.
There are millions of protein factories in every cell. Surprise, they’re not all the same
Rough ER is also a membrane factory for the cell; it grows in place by adding membrane proteins and phospholipids to its own membrane.
Endoplasmic reticulum: Scientists image 'parking garage' helix structure in protein-making factory
Theoretical biologists at Los Alamos National Laboratory have used a New Mexico supercomputer to aid an international research team in untangling another mystery related to ribosomes -- those enigmatic jumbles of molecules that are the protein factories of living cells.
The molecular factory that translates the information from RNA to proteins is called the "ribosome"
Quality control in the endoplasmic reticulum protein factory
The endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and where stringent quality-control systems ensure that only correctly folded proteins are sent to their final destinations. The changing needs of the ER factory are monitored by integrated signalling pathways that constantly adjust the levels of folding assistants.
Molecular factories: The combination between nature and chemistry is functional
The brain is a " Uber-Computer "
https://reasonandscience.catsboard.com/t2734-the-brain-is-a-uber-computer-far-more-sophisticated-that-man-made-computers
The Cell is a super computer
https://reasonandscience.catsboard.com/t2712-the-cell-is-a-super-computer?highlight=computer
Your Cortex Contains 17 Billion Computers
Yes, the brain is a computer…
An 83,000-Processor Supercomputer Can Only Match 1% of Your Brain
Why cells are like computers—And how ‘hacking’ them could lead to new diagnostic tools
Hidden Computational Power Found in the Arms of Neurons
Dendritic action potentials and computation in human layer 2/3 cortical neurons
Single neuron dynamics and computation
What can a single neuron compute?
Brain-Inspired Computing Could Lead to Better Neuroscience
Neurons are transistors
Synaptic transistor
https://en.wikipedia.org/wiki/Synaptic_transistor
Neuron transistor behaves like a brain neuron - Phys.org
Digital: From Neurons to Transistors - LinkedIn
Capacitive neural network with neuro-transistors | Nature
A neuron-astrocyte transistor-like model for neuromorphic dressed neurons.
Electrolyte-gated organic synapse transistor interfaced ... - arXiv
1. Máquinas, robôs, linhas de produção de manufatura totalmente automatizadas, transportadores, turbinas, transistores, computadores e fábricas são sempre configurados por designers inteligentes
2. A ciência descobriu que as células são literalmente nanofábricas químicas que operam com base em máquinas moleculares, robôs de proteína, transportadores de proteína cinesina, linhas de produção autônomas autorreguladas, geram energia por meio de turbinas, transistores de neurônios e computadores
3. Portanto, muito provavelmente, as fábricas de células contendo todas essas coisas são o produto de um projetista inteligente.
https://reasonandscience.catsboard.com/t2978-nature-s-robots-point-to-design
Máquinas moleculares
https://reasonandscience.catsboard.com/t1289-molecular-machines-in-biology
https://en.wikipedia.org/wiki/Molecular_machine
Science papers:
1.“Biological machines: from mills to molecules,” Nature Reviews Molecular Cell Biology, Vol. 1:149-153 (November, 2000).
2.Thomas Köcher & Giulio Superti-Furga, "Mass spectrometry-based functional proteomics: from molecular machines to protein networks," Nature Methods (October, 2007).
3."Crystalline Molecular Machines: A Quest Toward Solid-State Dynamics and Function," Accounts of Chemical Research, Vol. 39(6):413-422 (2006).
4."Molecular Machines," Annual Review of Biomedical Engineering, Vol. 6:363-395 (2004).
5."The Closest Look Ever At The Cell's Machines,” ScienceDaily.com (January 24, 2006).
6."The Cell as a Collection of Protein Machines: Preparing the Next Generation of Molecular Biologists," Cell, Vol. 92:291 (February 6, 1998).
7.Walter Neupert, "Highlight: Molecular Machines," Biological Chemistry, Vol. 386:711(August, 2005).
8.Seiji Kojima and David F. Blair, “The Bacterial Flagellar Motor: Structure and Function of a Complex Molecular Machine,” International Review of Cytology, Vol. 233:93-134 (2004).
9.Hugo ten Cate, “The blood coagulation system as a molecular machine,” BioEssays, Vol. 25:1220-1228 (2003).
10.John L Woolford, Jr, “Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines,” Current Opinion in Cell Biology, Vol. 21(1):109-118 (February, 2009).
11.Reinhard Lührmann, "The Spliceosome: Design Principles of a Dynamic RNP Machine," Cell, Vol. 136: 701-718 (February 20, 2009).
12.Timothy W. Nilsen, "The spliceosome: the most complex macromolecular machine in the cell?," BioEssays, Vol. 25:1147-1149 (2003).
13.L. Yarmush, "Molecular Machines," Annual Review of Biomedical Engineering, Vol. 6:363-395 (2004);
14.Paul D. Boyer, "The ATP Synthase--A Splendid Molecular Machine," Vol. 66:717-749 (1997);
15.Steven M. Block, "Real engines of creation," Nature, Vol. 386:217-219 (March 20, 1997).
16.C. Mavroidis, A. Dubey, and M.L. Yarmush, "Molecular Machines," Annual Review of Biomedical Engineering, Vol. 6:363-395 (2004)
17.Ronald D. Vale, “The Molecular Motor Toolbox for Intracellular Transport,” Cell, Vol. 112:467-480 (February 21, 2003).
18.Sharyn A. Endow, “Kinesin motors as molecular machines,” BioEssays, Vol. 25:1212-1219 (2003).
19.Michiel Meijer, “Mitochondrial biogenesis: The Tom and Tim machine,” Current Biology, Vol. 7:R100-R103 (1997).
20.Maurizio Brunori, "Structure and function of a molecular machine: cytochrome c oxidase," Biophysical Chemistry, Vol. 54: 1-33 (1995).
21.Robert T. Sauer, “Structures of Asymmetric ClpX Hexamers Reveal Nucleotide-Dependent Motions in a AAA+ Protein-Unfolding Machine,” Cell, Vol. 139:744-756 (November 13, 2009).
Proteins are robots
Nature's robots: A history of proteins: Tanford, C., Reynolds, J
Shape-shifting molecular robots respond to DNA signals
When Nature's Robots Go Rogue: Exploring Protein ...
- Document - Nature's Robots: a History of Proteins - Gale
Bio-Inspired Self-Organizing Robotic Systems
GACR - Proteins - Multi-robot Systems
Buy Nature's Robots: A History of Proteins Book Online at Low ...
Molecular production lines
A molecular production line | Nature Chemistry
molecular assembly line | News and features
The molecular biology of production cell lines. - NCBI
Cell-Like 'Molecular Assembly Lines' of ... - Cordis
Biologically inspired molecular assembly lines - MIT Media Lab
DNA-based assembly lines and nanofactories
Cell factories
https://reasonandscience.catsboard.com/t2245-abiogenesis-the-factory-maker-argument
Microbial cell factory is an approach to bioengineering which considers microbial cells as a production facility in which the optimization process largely depends on metabolic engineering
https://en.wikipedia.org/wiki/Microbial_cell_factory
Science papers:
The Molecular Fabric of Cells BIOTOL, B.C. Currell and R C.E Dam-Mieras (Auth.)
Plant Cells as Chemical Factories: Control and Recovery of Valuable Products
Fine Tuning our Cellular Factories: Sirtuins in Mitochondrial Biology
Cells As Molecular Factories
Eukaryotic cells are molecular factories in two senses: cells produce molecules and cells are made up of molecules.
Ribosome: Lessons of a molecular factory construction
Nucleolus: the ribosome factory
Ribosome: The cell city's factories
The Cell's Protein Factory in Action
What looks like a jumble of rubber bands and twisty ties is the ribosome, the cellular protein factory.
Chloroplasts are the microscopic factories on which all life on Earth is based.
Visualization of the active expression site locus by tagging with green fluorescent protein shows that it is specifically located at this unique pol I transcriptional factory.
There are millions of protein factories in every cell. Surprise, they’re not all the same
Rough ER is also a membrane factory for the cell; it grows in place by adding membrane proteins and phospholipids to its own membrane.
Endoplasmic reticulum: Scientists image 'parking garage' helix structure in protein-making factory
Theoretical biologists at Los Alamos National Laboratory have used a New Mexico supercomputer to aid an international research team in untangling another mystery related to ribosomes -- those enigmatic jumbles of molecules that are the protein factories of living cells.
The molecular factory that translates the information from RNA to proteins is called the "ribosome"
Quality control in the endoplasmic reticulum protein factory
The endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and where stringent quality-control systems ensure that only correctly folded proteins are sent to their final destinations. The changing needs of the ER factory are monitored by integrated signalling pathways that constantly adjust the levels of folding assistants.
Molecular factories: The combination between nature and chemistry is functional
The brain is a " Uber-Computer "
https://reasonandscience.catsboard.com/t2734-the-brain-is-a-uber-computer-far-more-sophisticated-that-man-made-computers
The Cell is a super computer
https://reasonandscience.catsboard.com/t2712-the-cell-is-a-super-computer?highlight=computer
Your Cortex Contains 17 Billion Computers
Yes, the brain is a computer…
An 83,000-Processor Supercomputer Can Only Match 1% of Your Brain
Why cells are like computers—And how ‘hacking’ them could lead to new diagnostic tools
Hidden Computational Power Found in the Arms of Neurons
Dendritic action potentials and computation in human layer 2/3 cortical neurons
Single neuron dynamics and computation
What can a single neuron compute?
Brain-Inspired Computing Could Lead to Better Neuroscience
Neurons are transistors
Synaptic transistor
https://en.wikipedia.org/wiki/Synaptic_transistor
Neuron transistor behaves like a brain neuron - Phys.org
Digital: From Neurons to Transistors - LinkedIn
Capacitive neural network with neuro-transistors | Nature
A neuron-astrocyte transistor-like model for neuromorphic dressed neurons.
Electrolyte-gated organic synapse transistor interfaced ... - arXiv